Symbol
Name
ID

Camk2a
calcium/calmodulin-dependent protein kinase II alpha
MGI:88256

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Spasticity

Thick corpus callosum

Hyperintensity of cerebral white matter on MRI

Involuntary movements

EEG abnormality

Interictal epileptiform activity

Absent speech

Delayed speech and language development

Irritability

Intellectual disability

Intellectual disability, severe

Sleep-wake cycle disturbance

Inability to walk

Unsteady gait

Global developmental delay

Delayed gross motor development

Delayed ability to walk

Bilateral tonic-clonic seizure

Generalized non-motor (absence) seizure

Febrile seizure (within the age range of 3 months to 6 years)

Myoclonic seizure

Disease(s) Associated with CAMK2A

autosomal dominant intellectual developmental disorder 53

autosomal recessive intellectual developmental disorder 63

Mouse Phenotypes

nervous system phenotype

seizures

sporadic seizures

increased cerebral infarct size

abnormal dentate gyrus morphology

abnormal hippocampus granule cell morphology

abnormal neuron morphology

abnormal dendrite morphology

abnormal synapse morphology

abnormal postsynaptic density morphology

abnormal synaptic vesicle morphology

abnormal synaptic vesicle number

abnormal cutaneous/subcutaneous mechanoreceptor morphology

abnormal neuron physiology

abnormal synaptic plasticity

impaired synaptic plasticity

abnormal synaptic transmission

abnormal CNS synaptic transmission

abnormal excitatory postsynaptic currents

abnormal excitatory postsynaptic potential

abnormal long-term potentiation

enhanced long-term potentiation

reduced long-term potentiation

abnormal long-term depression

absent long-term depression

reduced long-term depression

decreased paired-pulse facilitation

Availability

Mouse Genotype

Camk2a^tm1.1Oyam/Camk2a^tm1.1Oyam

Camk2a^tm1Kub/Camk2a^tm1Kub

Camk2a^tm1Mllr/Camk2a^tm1Mllr

Camk2a^tm1Sva/Camk2a^tm1Sva

Camk2a^tm2Sva/Camk2a^tm2Sva

Camk2a^tm3Sva/Camk2a^tm3Sva

Camk2a^tm4Sva/Camk2a^tm4Sva

Camk2a^tm5Sva/Camk2a^tm5Sva

Camk2a^tm1.1Oyam/Camk2a⁺

Camk2a^tm1Sva/Camk2a⁺

Camk2a^tm5Sva/Camk2a⁺

Camk2a^tm1.1Yelg/Camk2a^tm1.1Yelg
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Camk2a^tm1Vyb/Camk2a^tm1Vyb
Tg(Grik4-cre)G32-4Stl/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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